Dr. Angelo H. ALL
Associate Professor, Department of Chemistry
- SYSTEM HEALTH
The focus of my research is on nervous system injury, repair, regeneration and modulation. My laboratory has pioneered the monitoring and quantitative analysis of neuro-electrophysiological signals in order to assess the electrical integrity of nervous system at various stages. My mostly translational research projects involve acute hypothermia treatment as well as stem cell replacement therapy derived from human embryonic stem cells, human iPS cells, and direct conversion by trans-differentiation of human adult cells. These stem cells are also modified to induce overexpression of neurotrophic factors in order to modulate the lesion microenvironment and stimulate endogenous regenerative responses post injury. A part of my laboratory is also investigating application of upconversion nanoparticles in conjunction with near infrared illumination system for the neuromodulation applications both in vitro and in vivo. The goal is to develop a semi-invasive tool for stimulating or inhibiting, with spatio-temporal precision, neuropathways situated deep in the nervous system (spinal cord, motor cortex, vagus nerve, etc.) selectively.
In addition, my laboratory is studying the adult central nervous system capabilities of adaptive changes enabling reorganization and plasticity in spared neuropathways following neuro-trauma. I have also used different imaging techniques to monitor anatomical changes in contused spinal cord architectures and brain at various time points enabling me to identify spared fibers (anatomically intact but nonfunctional neuropathways) and tracking the extent of secondary injury to determine the therapeutic benefits of the various treatment strategies.